You are handsome, rich and powerful.
Imagine a world where a good book like To Kill a Mocking Bird is bought out of the copyright slavery so that everybody could download, publish and translate it to any language.
You can do it.
ThAt's a #cause.
Evening by my time Mr President, if this is really the true handle of the 44th President of the United States of America. And since I got a follow up from this handle, I will and must confess that I am grateful. It's once in a rare scene I will ever get this, *Proud and Grateful*. :)
Mr. President, since you have followed me, I would appreciate If you would write a reference letter for me, the person who is going to get his Computer Engineering degree in December. At least I had the motivation/courage the ask. Thank you =) ( odds are low, hope isn't lost )
Making Personalised medicine a Reality - Technical & logistical challenges,
Data + Steps toward solutions.
– Dear President #Obama, I've read a book of yours in which you talked about your own family experience with cancer. I'm aware that you're a good man who genuinely cares about cancer.
You'll probably never get to read this, but If it was possible I’d like to share the detail with you.
If clearly informed about important obstacles, you could be the man to make a “really big” difference in solving the most expensive issue in cancer and overcoming a barrier to saving Lives & Resources.
Innovation in medicine is too often stifled by seasoned grant grabbers & business people in white lab coats. People skilled at accessing public funding.
Most of today's #Cancers tests (Bio-Markers) are very far from being good, never mind perfect. ideally these test need to be carried out monthly to try gaining useful early information on whether or not a patient is benefiting from an expensive treatment. (excessive pricing often means this does not happen in practice)
Current industry is still free to milk margins on these tests to the max,
There are several new approaches to bio-markers, these focus on capturing detached/circulating tumour cells, RNA or DNA.
Sadly these tests are also to expensive to use in many big trials never mind for most patients.
Sometimes the government needs to step in to get us over hurdles. In cases like this government could help bust virtual monopolies by providing a small but competing model in R&D.
A solution worth focusing on would be a "dedicated government program" to focus on the development of "ultra-low-cost" bio-markers
This would involve some brave steps that may upset Industry players.
>Separating some public R&D funding from current industry models which serve investor returns as opposed to savings.
>Seeking out & funding fresh passionate scientist to develop technologies which would be licensed for production by government - as opposed to having publicly funded cancer products sold on to those with a poor tract record in delivering anything at a fair price.
The same approach could benefit other big expensive medical challenges too.
Data & references
Cancer blind treatment approaches - Biomarkers (Cancer Tests): Can We Turn Recent Failures into Success?
Evaluation of cancer biomarkers: clinical and computational
Includes table with predictive values (PPV & NPV)
Why there’s more to "genetics" than mapping your genes
Epigenetics "an introduction"
Personalized Cancer Care: Where it Stands Today